Free shipping on all domestic orders over $39

What Is It: Kinetin and Kinerase

Is a Solution for:
Sagging Skin
September 5, 2008 Reviewed by Marta 2 Comments
Perhaps Sephora's customers are devoted fans of Courtney Cox. Otherwise, I don't really understand why they would vote Kinerase Intensive Eye Cream ($59) a "2008 Winner". The only other explanation, is that they are big believers in the power of kinetin.

There is precious little else of interest in this Kinerase eye cream, so it behooves us to see if kinetin derserves to be a show stealer. N6-Furfuryladenine is the synthetic version of kinetin, a plant hormone (or cytokinin) that regulates cell growth. It is a relative newcomer to the cosmetic scene and there is scant research to prove that topical application has any effect.

There is one seemingly independent, 48-week clinical study, conducted in 1996 at the University of California at Irvine (until it becomes clear that it was under the direction of Gerald D. Weinstein, M.D., who happens to be on the advisory board of Senetec, the company that makes kinetin). Not surprisingly, N6-furfuryladenine was found to be safe and effective in partially reversing the clinical signs of photodamaged facial skin during extended use. It was was effective in reducing the appearance of fine lines and wrinkles, blotchy hyperpigmentation, telangiectasia and tactile skin roughness.

In 2002, a researcher at the Department of Cellular Aging at the University of Denmark, wrote: "Although the exact mechanism of its action is not fully understood, kinetin appears to be a powerful natural antioxidant with pluripotent effects in protecting DNA and protein from oxidative and glyoxidative damage. Further applications of kinetin in health care and biomedicine need to be investigated thoroughly." Hmmm, I'm sure there's no connection to the fact that another Sentec advisory board member, Dr Brian Clark, hails from the University of Denmark.

A 1999 study concluded that it provided 50% protection against oxidative DNA damage at a concentration of 100 uM.

So far, not bad. But not spectacular. And what of the claims that kinetin is a viable alternative to retinol for those of sensitive skin? A study that compared kinetin - favorably - to Renova (a prescription retinol, or tretinoin cream) turned out to be funded by the manufacturer of N6-Furfuryladenine. The manufacturer also conducted a study in Taiwan that conluded that N6-Furfuryladenine works even better if combined with niacinamide. Kinerase has not followed this advice.

Kinetin may have some impact on aging skin. But compared to good peptides such as matrixyl 3000, it doesn't seem to have earned enough kudos to qualify for center stage.

Shop Skincare RX for Kinerase Intensive Eye Cream

Ingredients in Kinerase Intensive Eye Cream

Purified Water, Glyceryl Stearate And Laureth-23, Isopropyl Palmitate, Propylene Glycol, Stearic Acid, Cetyl Alcohol, Carthamus Tinctorius (Safflower) Seed Oil, Soya Sterol, Stearyl Alcohol, Dimethicone, Imidazolidinyl Urea, Citric Acid, Sodium Hydroxide, Methylparaben, Soluble Collagen, Carbomer, N6-Furfuryladenine, Panthenol, Propylparaben, Triethanolamine, Ascorbic Acid, Hydrolyzed Elastin,  Aloe Barbadensis Leaf Juice.
  • August 31, 2017

    by Lori

    I started using Kinerase about 17 years ago. Then suddenly I wasn't able to order it through Target pharmacy or any other ! That happened about 5 years ago maybe longer ? Then I went to
    Amazon and bought the intensive cream for ageing skin . I knew it was either fake ( With the real price tag ! ) OR
    it was very old and probably expired by at least 2 - 3 years !
    I called Amazon & told C.S that it smelled so bad , I almost got sick !
    She said I was welcome to send both the day & night creams back . However not being able to get it anywhere else . I kept it . I've been out now for 2 years at least.
    My skin looks horrable ! I look so much older and I know it's because i don't know where to find it anymore . I'm on a fixed income, Yet I'd go without whatever that month ; to buy my Kinerase
    There's NO way I can afford botox , or anything else for that matter . I knew Kinerase worked for me , and even though I wouldn't be able to pay bills that month , it lasted just long enough for me to " catch up " until I needed more .
    If anyone knows where I can get the real stuff , or even something better . Please let me know .
    I would be extremely grateful forever ♡
    Thank you
    Looking horrable lately in Boston Mass

  • August 26, 2010

    by Barbara

    I tried the Kinerase line, spent $130 on a package that was supposed to erase fine lines and brown spots. I've used nearly all of the products and haven't seen one bit of difference in my skin. A total waste of time and money. I'm glad Courtney Cox is so enamored of it, of course it helps to have been Botoxed into smooth perfection too. I'll save my money up for that.

Join the discussion! Leave a comment below.

My Comment

Add a comment...

-or- Cancel Comment
* Required Fields
truth in aging's five best

Truth In Aging's Five Best

The very best to choose from for your skin concerns.

Read More

truth in aging videos

Truth In Aging Videos

Helpful how-tos and reviews from Marta and friends.

Watch Now

meet our contributors

Meet Our Contributors

The TIA community consists of our trusted reviewers.

Meet Them

be inspired

Be Inspired

Inspiring thoughts and women who are aging gracefully.

Read More