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What is it: Acetyl hexapeptide-3

November 21, 2007 Reviewed by Marta 2 Comments

When I came across Athena 7-minute Facelift with these before and after pictures, my first thought was that I had found my next victim (um, subject) for Dept of Daft.

I particularly liked the claim on the Athena website that "in seven minutes it significantly reduced the appearance of fine lines and facial wrinkles an average of 83.7% on a full face evaluation". And all this with only natural ingredients. That's some cream.

I guess you could say, strictly speaking, that the active ingredient Acetyl Hexapeptide-3 (also known as Argireline) is natural.  It is an artificially created peptide (a chain of six amino acids) that was developed by a Spanish company and it works by limiting the neurotransmitters that tell your facial muscles to move (so the effect is a bit like Botox).

At a 10% concentration and used over 30 days it can reduce the appearance of wrinkles by 30%. This was based on a test of eight women. This is cited by every manufacturer that uses the stuff and is the study behind the 83.7% effective claim made by Athena. Acetyl Hexapeptide-3 is in a suprising number of products: Creme De Vie, Pretox, Cellular Skin Rx and La Prarie to name but a few.

If my experience is anything to go by, don't expect long-lasting change. Acetyl Hexapeptide-3 is the key ingredient in Avetone and I've been using that for about a year without any noticable effects (good or bad) and I'm going to stop once I've finished up the pot I'm currently using.

  • September 12, 2017

    by Bernice

    I would like to make a comment on Argireline (acetyle hexapeptide-3) I started using it about 4 weeks ago, Because I was having involuntary muscular movement in my face, ( I have MS) I added matrixyl with it, I have seen a big different in my skin and the movement that was in my face has stopped, I don't think just using one peptide is the answer I think using different one's together and different product is what worked for me, I am 64 years old, when I am with my son people think I am his wife. My son is 40, We women has to take control of our own skin care health, do research on products that we add to our body, I did research on different products until I learn how to make my own skin care products, I love using Argireline, just keep using it but with other peptides and other skin products like vitamin C and ferulic acid they work very well, I want to thank you for your information.

  • June 8, 2009

    by Meir S.

    Dear Marta
    I wasrealy surprised to read your realistic view on the use of Argireline - Acetyl Hexapeptide-3. You said "without any noticable effects (good or bad) " This is god point scientific test that compared Botox to Argireline peptide commercial preparation cameto the same conclusion.
    lmost every company which place the peptide and probably at much lower than the 10% used in the original test. Almost no one confirmed the original results when using lower amountr of the peptide. I think that some of the creams are very good but probably do not deliver the effect of Botox as you find out by personal use. I am writing this as person whoworked more than 10 years in developing personal care products,


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