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Deciem NIOD Multi-Molecular Hyaluronic Complex Review

is a Solution for:
Fine Lines, Wrinkles
niod multi-molecular hyaluronic complex
March 14, 2016 Reviewed by TIA Community Member 4 Comments
TRU Rating
A hyaluronic acid serum that penetrates and protects


Smoothes and plumps skin



by Ann P.

Hyaluronic acid can hold as much as 1,000 times its weight in water and although the body produces it naturally, the levels decrease as one ages, which is why it’s an important part of my daily regimen as I near 50 and my skin becomes drier. I was a little hesitant to try the NIOD Multi-Molecular Hyaluronic Complex (MMHC) ($35 in the shop) because I was already using a hyaluronic serum that I liked, but I had recently read about low molecular-weight hyaluronic acid, and the broad spectrum of hyaluronic compounds (twelve!) in the NIOD product made me curious to give it a try.

Just to give a little background, NIOD (Non–Invasive Options in Dermal Science) is one product line of the Deciem company, based in Canada. Each product line has a different focus, with NIOD being cutting-edge skincare with a focus on overall skin health and long term results.

The NIOD website gives a thorough description of the twelve hyaluronics that make up MMHC, but what stood out for me was the mix of high, mid and low molecular weight compounds, as well as plant-based compounds and a fermented high molecular weight hyaluronic acid to prevent moisture loss.

But it was the low molecular weight compounds that truly intrigued me. These smaller molecules are supposed to penetrate deeper and hydrate the skin from within, even stimulating the body’s own production of hyaluronic acid and collagen. Most hyaluronic acid serums contain high-weight molecules which are larger and cannot be absorbed by the skin, but instead form a protective layer on the surface. By combining high and low weight, one gets the best of both worlds.

In my research for this review I came across some studies that suggest low molecular weight hyaluronic acid can cause inflammation, but other studies suggest that rather than contributing to inflammation, low molecular weight hyaluronic acid can have a calming effect on rosacea and other skin irritations (source). With so much contradictory information out there, all I can say is that my own experience with MMHC was positive, with no outbreaks whatsoever.

The first thing I noticed about the product was that it’s thin and watery, unlike other hyaluronic serums I’ve used that were thicker and almost gel-like. Twice a day I put a few drops in my hand, rubbed my palms together and patted the serum onto my face, neck, décolleté and the backs of my hands. Unlike the hyaluronic serum I had been using previously, MMHC didn’t leave my skin feeling immediately silky, and I couldn’t help but wonder if it was going to do anything at all. But I had committed to thirty days, so I continued using it twice a day and by around the third or fourth day I could definitely see a change in my skin. It felt smoother and looked plumper. It was a subtle effect, but enough to convince me I was on the right track.

MMHC is priced very reasonably compared to other hyaluronics and is an outright steal compared to recent products on the market containing a blend of different molecular weights. Overall, I’m very impressed with the Niod Multi-Molecular Hyaluronic Complex and am glad my trial period has ended so I can start trying some of NIOD’s other products. This is an interesting company that bears watching!

  • February 26, 2018

    by Lindsay

    This question is,for,Betty. How do you make your own Hyaluronic Serum? Thank you

  • September 8, 2017

    by betty

    (4 out of 5)

    I purchased this out of curiosity because I make my own hyal serum with 3 molecular weights, low, medium and semi high. It has the same effect as the Deciem NIOD hyal. acid. The lower the molecular weight the thinner the product will be, I use the semi-high weight in mine to thicken it. So I will use up the bottle and go back to making my own as its cheaper and I add my own peptides etc. and natural preservatives.

  • March 14, 2016

    by Daniel

    I'm so glad you liked it :) in the Uk people are going crazy for the brand :) the 30% vitamin c serum with 10% niacinamide is also amazing :) the whole range is rather exciting :)

  • March 14, 2016

    by Janet

    Ann: I've become very interested in the Deciem brand, I have not used this particular product yet, but I know you'll be interested in the NIOD HYDRATION VACCINE. It works like nothing I've ever used, no oil, cream or lotion. My skin feels like there is a protective coating on it and it feels PLUMP! My skin has never felt like this...... It is impressive!!

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