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What Is It: Matrixyl

April 25, 2013 Reviewed by Marta 6 Comments

There are short-term anti-wrinkle systems and long-term ones. Amongst the short-term are superficial treatments such as Acetyl Hexapeptide-3 (or Argireline, which is the trademarked name for AH-3). Creams such as 24:7 Freeze, Athena 7 Minute Lift or Avetone are based on these. They are supposed to work on the muscles that cause wrinkle formation. It is the same principle as Botox, but much, much milder and lasts no more than an hour or so after application.

Long-term systems attempt to boost collagen production or repair DNA. These are obviously preferable so I am always on the look out for products that contain Matrixyl.

So what is Matrixyl? Basically, its a peptide. Creams these days frequently boast about being packed full of peptides, but are not specific as to which peptide is being referred to. Matrixyl is palmitoyl-pentapeptide 3 and this is a peptide that specifically stimulates collagen synthesis and skin repair. This means it qualifies as a long-term aging system.

However, there is something that might be even better than Matrixyl: Matrixyl 3000.

There is no point comparing Matrixyl and Matrixyl 3000 since the only thing they have in common is the name. Matrixyl 3000 is made from two new peptides that have nothing to do with the palmitoyl-pentapeptide 3 that is in the original matrixyl. The two new peptides are palmitoyl-tripeptide and palmitoyl-oligopeptide. They are supposed work synergistically to mimic the appearance of this broken down collagen, causing your skin to react by producing more collagen, as well as elastin. The company that owns the patent has conducted research on two panels of 23 volunteers aged from 39 to 74 to demonstrate that matrixyl 3000 is more effective than the original matrixyl at regulating skin cell activity. The data is limited, however.

Update: In early 2013 University of Reading researchers found that Matrixyl can nearly double the amount of the protein collagen needed to give skin its elasticity. The team is led by Professor Hamley, who is something of a peptide-file and has been looking at ways to stimulate collagen for wound healing. Read more.

See also:

Five Best Serums and Creams with Matrixyl

Five Best with Copper Peptides

See all our FIVE BEST recommendations

Check out all our products featuring Matrixyl & Matrixyl 3000


  • July 14, 2016

    by vanitha

    I would likebto receive information on your skin products

  • August 27, 2015

    by Shelley

    was wondering if there are any side effects from this product? thanks

  • April 5, 2015

    by Marta

    Hi Sandy, I'm not aware of a really good one with peptides, but you could look at Stemulation's Relance. It has growth factors to help boost skin cell production:

  • April 4, 2015

    by Sandy

    Is there any peptide product that can influence thin skin on arms.?

  • December 7, 2012

    by PURITY

    I would like to know the remedies of making matryxl cream. can I make it at home which vegetables or fruits do I use. It is a Wonderful cream

  • September 21, 2011

    by Smashbox Photo Finish SPF15 with Dermaxyl | A Girl's Gotta Spa! (sm) Top beauty blog, spa, hair care, makeup, beauty trends, skin care

    [...] guess is that Smashbox’s Dermaxyl is one of the collagen-boosting peptides that is known as Matrixyl 3000, palmitoyl oligopeptide, and antioxidant green tea and grape seed extracts. Plus there’s [...]

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