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Deciem NIOD Copper Amino Isolate Serum 2.1

Five Best with Copper Peptides 2016

Size: 0.5 oz (15 ml) Deciem is currently reformulating this product

Deciem’s NIOD Copper Amino Isolate Serum 2.1 has been revised to contain a 2% concentration of pure copper tripeptide-1, a peptide that assists in wrinkle reduction for a smoother, firmer complexion. Copper peptides provide a pivotal role in healthy skin function, promoting collagen formation and reducing inflammation. With this powerful active at its core, we're confident that you'll see firmer and healthier skin when you use this serum continually. Although the presence of this peptide in skin tissue declines as we age, NIOD Copper Amino Isolate Serum delivers a high concentration of copper tripeptide-1 in the form of an easy-to-use serum. When combined with a one-time activator that contains a blend of hydrating sodium hyaluronate and supportive peptides, the copper concentrate penetrates the skin’s surface working to replenish and invigorate. For those looking for a even heavier hit, the same Copper Amino Isolate Serum is made in a 5% formula to greater off set wrinkles and help smooth skin.

Tested for 30 days and recommended by Marta: As members of the Truth In Aging community well know, one of my favorite ingredients is copper peptides. This ingredient is a powerful booster of collagen and restorer of hair with a long and rich research history going back to the 1970s. So Deciem’s NIOD Copper Amino Isolate Serum 2.1 had me at hello.

The copper used here is a tripeptide, meaning that it has been combined with three amino acids. I was able to mentally reference the fact that in my Truth Vitality Advanced Complex for hair, the key active is copper with five amino acids. What makes NIOD’s face serum neat is that it packages the copper tripeptide-1 part of the formula separately and you mix it with what they call an activator, a copper salt from two more amino acids. The 1% that Deciem boasts about is actually worth the hubris, as research has been conducted at 0.68% and produced results on inflammation.

Talking of hubris, it is claimed that this serum will make you younger looking in only five days. I am not so sure I can concur with that, but after a month of testing it, I am convinced that it should be part of my regimen. I didn't particularly notice wrinkle reduction as a result of my test. That may come later. But where NIOD seemed to really be helping was with firming, especially my lower cheeks and sides of my mouth going to the chin. This is where sagging tends to begin for me and I believe that the copper peptides (along with ultrasound and LED) made a difference.

NIOD Copper Amino Isolate Serum 1% really is a serum and does not for one minute pose as a moisturizer or even as a serum that can be used on its own. My slightly oily skin can often wear a serum without the need to layer a moisturizer, but not in this case. Despite the low-molecular version of sodium hyaluronate, this serum is very drying without an additional moisturizer. One reason for this may be that it includes myristoyl nonapeptide-3, a peptide that is said to mimic retinol and exfoliate the skin in order to encourage cell turnover. There’s not much research on this ingredient that I can find. I was intrigued to see some decapeptides and an oligopeptide and discovered that along with wheat protein they are marketed as an ingredient called Renaissance Powder. The manufacturer promises it will regenerate the skin and minimize scars. There are a couple of potential toxins amongst the preservatives and solvent that could be irritating. I had no adverse reactions. Overall, I would heartily recommend this to anyone wanting to introduce collagen-boosting copper into their skincare routine.

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$ 60.00
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Our Take

As members of the Truth In Aging community well know, one of my favorite ingredients is copper peptides. This ingredient is a powerful booster of collagen and restorer of hair with a long and rich research history going back to the 1970s. So Deciem’s NIOD Copper Amino Isolate Serum 1% ($60 in the... read more

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5 member(s) found this review helpful


19 Reviews
  • Jenn

    (5 out of 5)

    NIOD Copper Amino Isolate Serum 1.00% was my second attempt at trying a "copper" product, having first tried Medik8 Firewall. Unlike
    most other reviewers, I didn't find Firewall to be the magical product that many others have found it to be. I figured that if I wanted to test out copper as a single ingredient that I'd try NIOD's Copper product. Immediately, I appreciated that i had to mix the powder in its Solution, which made me feel as if the product was "fresh," so to speak, because it isn't activated until you mix the powder and solution together. I use the product, both day and night, after washing and patting my face dry, prior to any serums or creams. It's a violet-colored, watery solution, dispensed from a I just dispense it a couple small drops at a time, apply, and repeat until I've covered my face, neck and décolleté. Within about 10 days I noticed small changes--my face just seemed to look a bit more even toned, and a smidge brighter. By the time I'd used up my first bottle, after about 5 weeks, my tone was significantly brighter and far more even, to a point that I stopped using Foundation products entirely, opting for tinted moisturizer with just a little concealer under my eyes and on a couple minor, lingering spots. I've even felt comfortable going without any tinted products at all on my usual "light makeup" days.
    I haven't found, after one bottle, that there are significant changes in my mild wrinkles (marionette lines, forehead wrinkles, crows feet), but I have other products that address those issues and do a pretty good job. This particular product, after trying out several other heavy-hitters that highlight copper, is my HG, 110%, for brightening and evening skin tone, and I can't wait to see what improvements I may see as I begin to use my 2nd bottle! I recommend this without any reservation. Great stuff!!!

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  • Sonoko


    I also use DDG's Vit C Peptide Oil with CAIS. I apply CAIS first and wait 30 second before applying the oil. So far, working out great. :-)

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  • Sonoko

    (5 out of 5)

    My Goodness. Deciem is my new absolutely favorite company. Especially the NIOD line. I also love the founder's attitude, personality and unique innovative approach.
    I was interested in copper product and decided to try this after reading great reviews and affordable price compared to other brand.
    This is such an amazing product. It is watery and absorbs into skin super fast. I like to use couple drops on my finger and applied it on each part of my face. I've had no adverse reaction.
    I've read that this product is the basis of NIOD line and if you are deciding on just one product to have from this brand, make it this one! (Also learned that both 5% and 1% will offer same results after few month time)
    Love that NIOD focuses more on the roots of the aging and more on the longer term skin health unlike Hylamide, which targets more on specific condition of skin. So I may not be able to see results in short amount of time using NIOD alone, but my over all skin health would come out better in longer term. (but curiosity in me will be trying out Hylamide together with NIOD :-) ) I often feel that some product works very well but if I don't continue the use, all the improvement I've experienced from using the product just disappears like a temporary fix. So it would be great if I don't face the same skin problem or condition year after year.
    It is also working out great using around the eyes. After using some month, my skin overall look more healthier and brighter.

    Important thing I learned when using this product is that CAIS will be destroyed with any acidic pH. It is recommended to use CAIS first after cleansing (if cleanser is not acidic) and wait 30 second before applying any acidic product (vitamin C, peel, etc). If acidic product was used prior to CAIS, it is recommended to wait 30 minutes before applying CAIS.

    I'm slowly incorporating more products from Deciem (I love MMHC too) and I am so excited! I am planning on trying out all of them if I'm able!

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  • Marta

    Hi Shalini, yes you can layer vitamin C over it. The worry about vitamin C cancelling out copper peptides is an urban/internet myth that I have debunked as best I can in a couple of articles such as this one:

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  • Shalini

    (5 out of 5)

    I absolutely love (actually adore) this little potion. I can say definitively that this is the best addition to the anti-ageing arsenal. Marta.. quick question: can I layer the dr Dennis gross vitamin c +peptide oil over the serum? Or any other vitamin c over this serum for that matter? Just don't want to cancel out the efficacy of either of the ingredients. Please advise... thank you!!

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  • Svetlana

    (5 out of 5)

    I have been using the Deciem NIOD Copper Amino Isolate Serum 1.00% for a couple of months now and absolutely love it. I can honestly say that no other product has been so effective so fast. My skin looks firmer and feels healthier ... and it started to show within a week of use. I have been recommending this product to all my friends.

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  • Anup

    (5 out of 5)

    I think is one of the best priced copper serums out there in the market compared to the other over priced copper stuff.

    Best way to use this...apply a drop directly on the face / area,..trying to apply this with fingertips like other serums does not work as this sinks into the skin too fast.

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  • Preksha @ TIA

    Hi Shalini
    While 30-somethings can certainly use this product, I'd say it's an optimal choice for 40 & 50 somethings.

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  • Shalini

    (4 out of 5)

    What age group would this product be suited for? Can it be used by someone in their late 30s or early 40s?

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  • Marta

    Hi Marie, perhaps that question should be put to the EWG. It's impossible to be completely comprehensive, but maybe they'll look into them if you ask. In the meantime, you could take a look at our ingredients directory, where we have the safety and use profiles for thousands of ingredients:
    Otherwise, if you tell which ones you are interested in, I'd be glad to research them and add them to our directory.

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  • Marie

    Why are there several ingredients not listed in the SkinDeep database? This makes me hesitant to try if I cannot know the safety...

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  • Marta

    Hi Sherry, you could definitely use this along with ClarityRX. It's really just another couple of peptides and the copper peptides will boost the pro-collagen effects of the Matrixyl in ClarityRX. Actually, could be a very good combo. Let us know how you get on.

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  • Ray

    (5 out of 5)

    I've been using NIOD's Copper Peptide serum, and I think nothing has given me as dramatic a result as this in a week. Thankfully, unlike other Copper Peptides, NIOD does not insist on too many dos and donts. In fact, they even have a 30% Vitamin C serum ELAN included in their Copper Peptide regimen.

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  • Sherry

    I had started using ClarityRX Get Fit a couple of weeks prior to buying this copper serium and don't want to layer products that cancel each other out. Are these 2 products compatible? Also, the NIOD copper serum instructions also do not tell you how many droppers ..or drops.. to apply' as another reviewer mentioned. Any thoughts from Marta or the TIA community?

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  • Marta

    Hi Christian, I think that would be a great idea - Control and this copper serum would be very complimentary. Let us know how it works out.

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  • Christian

    Not a review, but a question... I see a previous reviewer is using this in combination with Your Best Face Control. I have been using Medik8 Firewall consistently, but am interested in trying Deciem’s NIOD Copper Amino Isolate Serum. Would you recommend layering Control over the Deciem serum, or applying them at separate times (for example, day and evneing)? I'm a fan of peptides such as Matrixyl and others found in both Control and Correct, so this intially seems liek a best-of-both-worlds pairing.


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  • Tae

    (5 out of 5)

    It may be too early to say for sure, but I think this serum is slowly but surely lifting my skin. I've been taking zinc supplements, and I had noticed really bad sagging around my cheeks and double chin. I read a study online which said supplementing with zinc could potentially lead to copper deficiency, which in turn could cause loss of elasticity, leading to sagging skin (check the label of your multi-vitamins!) Before I read about it, I had tried a lot of products aimed at lifting sagging skin, some of which did help restore some firmness to the skin, but none of which actually got rid of the sagging. Only a week into using this serum, the sagging is about 50% back to normal! I don't know if it's just this product, or the combination (this + YBF control + Mitoq) somehow hit the spot, but I'll definitely keep using this and see if I observe further improvement.

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  • Allison G.

    (4 out of 5)

    Well, it took longer for me to see results than 5 days, about the 10 day mark. Gradually over the month I noticed old acne scars and pigmentation were improving. I would describe it as a slow fade, so I am encouraged. The rough patches feel like the rest of my face now. At my regular time of the month for breakouts I at first had none, but they ended up being just a little late. My breakouts lasted for a shorter duration and my skin seemed to settle down quicker. Here is the part I was surprised at: no new discoloration left behind! As for my subcutaneous omnipresent pimple, he is nearly gone. Some days I can't feel it when I go in search.

    This serum suggests results over time. My initial experience leads me to consider this for continued use. I like the slow fade of unwanted skin issues and slow rising of healthier skin that happens simultaneously. I will continue using it. The only negative is the inclusion of phenoxyethanol, a potential irritant, last on the ingredients list.

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  • Susan

    (5 out of 5)

    I have only started using this over the weekend, but I have an observation as well as a question.

    My observation is I think this product is extremely effective -- again, this after only 5 or so days of using it. I have taken to using it before I use the LED feature of the Lux Renew. I took to heart Marta's encouragement that using a serum before the LED is not only fine but she noted studies commenting on increasing effectiveness. I do, indeed, think the combination has accelerated the results. At 52, my skin is in good shape, mostly from avoiding the sun since I was 15 I think, but excellent skin care throughout my life has also helped. That said, I have noticed lines in my forehead that I was curious to see if there were ways to soften. I have absolutely noticed that happening with the Copper Amino Serum plus LED.

    My question though is this: is there a correct amount of the serum to use? There was no specific instruction with the product other than how to mix the serum and activator and to use it twice a day. I'm operating a bit in the dark and I was wondering if there was an optimal amount to be used. I know more isn't always better. But less isn't always great either! So if I could get some wisdom on this, I'd really appreciate it.

    I will keep on using the Copper serum along with the LED and see what happens over a month. I certainly am curious to watch what occurs!


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  • Gail

    July 24, 2017


    I am on my 2nd bottle of CAIS serum 1% . There is a firmness that I can tell. Unsure about the wrinkle effect.
    I am 63 years old. I have used many products. This one is a keeper. I am using the neck serum. have been using for 3 days
    along with retina. I have high expections about it too. thanks for all your research.

  • Marta

    July 2, 2017


    Hi Cristina, retinols are best used alone and at night. However, if you must layer then retinol goes first, then wait 15 minutes before applying anything else

  • Cristina

    July 1, 2017


    Love this serum and been using it for a good while. I really wanted to introduce retinols to my routine ( i am REALLY getting old ;) ) . Also wondering if that would just not interfere with the CAIS. Also, better to use retinols before or after it? Thank you

  • Marta

    October 9, 2016


    Hi Shalini, glad to hear that you like this. You can certainly layer it under those other serums.

  • Shalini

    October 8, 2016

    (5 out of 5)

    This far I'm loving using this serum. I feel it really balances my skin and it just feels healthier. I do want to understand however, if I can layer either the Rejuvel or the stemulation hi impact serum on top of this? Will the efficacy of the ingredients be negated by layering any products? Thank you!

  • Lorna

    April 18, 2016



    Preksha recommended some products for me, which included a couple of Deciem products:-

    ~ NIOD Fractionated Eye-Contour Concentrate Serum (15ml), and
    ~ NIOD Copper Amino Isolate Serum 1.00% (30ml).

    The NIOD Copper Amino Isolate Serum 1.00% (30ml @ $60.00 in the TIA Shop) is also available in a 15ml bottle in the UK @ £38.00, or the full 30ml size @ £60.00.
    Aqua (Water), Sodium Hyaluronate Crosspolymer, Dimethyl Isosorbide, Ethoxydiglycol, Glycerin, Copper Tripeptide-1, Myristoyl Nonapeptide-3, Copper Lysinate/Prolinate, Zinc Palmitoyl Nonapeptide-14, Decapeptide-22, Ogliopeptide78, Palmitoyl Decapeptide-21, Methylglucoside Phosphate, Hydrolyzed Wheat Protein, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Pentylene Glycol, Ethylhexylglycerin, Xanthan Gum, Caprylyl Glycol, Glyceryl Caprylate, Phenylpropanol, Chlorphenesin, Phenoxyethanol.

    However, there is a NIOD Copper Amino Isolate Serum available in a 5% version in the UK too (15ml @ £130.00). The ingredients listed for this 5% Copper Amino Isolate Serum are as follows:-
    Glycerin, Copper Tripeptide-1, Aqua (Water), Methylglucoside Phosphate, Copper Lysinate/Prolinate, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Chlorphenesin, Phenoxyethanol.
    Aqua (Water), Sodium Hyaluronate Crosspolymer, Glycerin, Dimethyl Isosorbide, Ethoxydiglycol, Decapeptide-22, Ogliopeptide-78, Palmitoyl Decapeptide-21, Zinc Palmitoyl Nonapeptide-14, Myristoyl Nonapeptide-3, Hydrolyzed Wheat Protein, Pentylene Glycol, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Xanthan Gum, Caprylyl Glycol, Glyceryl Caprylate, Phenylpropanol, Ethylhexylglycerin, Chlorphenesin, Phenoxyethanol.

    Would you advise I started out with the NIOD 1% version, or should I risk the added power of the 5% Copper Amino Isolate Serum?

    I'd appreciate your advice!

    Many thanks,


  • Aqua (Water)
  • Sodium Hyaluronate Crosspolymer
  • Dimethyl Isosorbide
  • Ethoxydiglycol
  • Glycerin
  • Copper Tripeptide-1
  • Myristoyl Nonapeptide-3
  • Copper Lysinate/Prolinate
  • Zinc Palmitoyl Nonapeptide-14
  • Decapeptide-22
  • Ogliopeptide78
  • Palmitoyl Decapeptide-21
  • Methylglucoside Phosphate
  • Hydrolyzed Wheat Protein
  • PPG-26-Buteth-26
  • PEG-40 Hydrogenated Castor Oil
  • Pentylene Glycol
  • Ethylhexylglycerin
  • Xanthan Gum
  • Caprylyl Glycol
  • Glyceryl Caprylate
  • Phenylpropanol
  • Chlorphenesin
  • Phenoxyethanol
Dispense the entire contents of the Activator into the Serum. We recommend using this serum as the first step of your skin care regimen, after cleansing but before the application of other skin treatments.

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